Antibodies lock arms against HIV
نویسندگان
چکیده
منابع مشابه
Bispecific Antibodies Against HIV
Synergistic bispecific antibodies against HIV exhibit extraordinary potency and breadth of neutralization as promising candidates for treatment and prevention.
متن کاملNon-Neutralizing Antibodies Directed against HIV and Their Functions
B cells produce a plethora of anti-HIV antibodies (Abs) but only few of them exhibit neutralizing activity. This was long considered a profound limitation for the enforcement of humoral immune responses against HIV-1 infection, especially since these neutralizing Abs (nAbs) are extremely difficult to induce. However, increasing evidence shows that additional non-neutralizing Abs play a signific...
متن کاملInducing Cross-Clade Neutralizing Antibodies against HIV-1 by Immunofocusing
BACKGROUND Although vaccines are important in preventing viral infections by inducing neutralizing antibodies (nAbs), HIV-1 has proven to be a difficult target and escapes humoral immunity through various mechanisms. We sought to test whether HIV-1 Env mimics may serve as immunogens. METHODOLOGY/PRINCIPAL FINDINGS Using random peptide phage display libraries, we identified the epitopes recogn...
متن کاملDesigner antigens for elicitation of broadly neutralizing antibodies against HIV
Broadly neutralizing antibodies (bNAbs) are a consistent protective immune correlate in human immunodeficiency virus (HIV) patients as well as in passive immunotherapy studies. The inability to elicit bNAbs is the core reason underlining the repeated failures in traditional HIV vaccine research. Rare monoclonal bNAbs against HIV, however, have been produced. The significance of producing and st...
متن کاملIdentification and specificity of broadly neutralizing antibodies against HIV
Beginning in 2009, studies of the humoral responses of HIV-positive individuals have led to the identification of scores, if not hundreds, of antibodies that are both broadly reactive and potently neutralizing. This development has provided renewed impetus toward an HIV vaccine and led directly to the development of novel immunogens. Advances in identification of donors with the most potent and...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2003
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri1168